Sustainable multicomponent indole synthesis with broad scope
نویسندگان
چکیده
A sustainable and energy efficient indole amide synthesis with a supreme ecological footprint as calculated by E -factor, process mass intensity atom economy.
منابع مشابه
A Sustainable Multicomponent Pyrimidine Synthesis.
Since alcohols are accessible from indigestible biomass (lignocellulose), the development of novel preferentially catalytic reactions in which alcohols are converted into important classes of fine chemicals is a central topic of sustainable synthesis. Multicomponent reactions are especially attractive in organic chemistry as they allow the synthesis of large libraries of diversely functionalize...
متن کاملSustainable synthesis of thioimidazoles via carbohydrate-based multicomponent reactions.
The synthesis of diversely functionalized thioimidazoles through a modern variant of the Marckwald reaction is presented. This new protocol utilizes unprotected carbohydrates as well as simple amine salts as sustainable and biorenewable starting materials. Importantly it was discovered that a bifurcated reaction pathway results from using aldoses and ketoses respectively, yielding distinct reac...
متن کاملCatalytic enantioselective aza-Henry reaction with broad substrate scope.
In situ generated azomethines from readily available precursors react with nitromethane in the presence of 120 mol % of CsOH.H2O and 12 mol % of quinine- and cinchonidine-derived quaternary ammonium chlorides to provide the corresponding aza-Henry adducts in good yields and very high selectivities. It represents the first general enantioselective aza-Henry method for azomethines derived from en...
متن کاملChimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope
A high-throughput screening protocol for evaluating chimeric, self-sufficient P450 biocatalysts and their mutants against a panel of substrates was developed, leading to the identification of a number of novel biooxidation activities.
متن کاملVictor Ambros: The broad scope of microRNAs
O nce, we thought we understood all there was to know about how gene expression is regulated: A cell can tinker with the expression level of a given protein's messenger RNA by modifying the activity, abundance, and type of transcription factors in the nucleus or with the RNA's stability once it is made. But then came a surprising story about a short RNA in C. elegans called lin-4, which didn't ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Green Chemistry
سال: 2022
ISSN: ['1463-9262', '1463-9270']
DOI: https://doi.org/10.1039/d2gc02060b